TO BE ADDED
CBD prevents the activity of the enzyme cytochrome P450 2C19 (Jiang et al. 2013). Enzymes of the cytochrome P450 complex are responsible for the degradation of medicinal drugs. Medicines that are degraded by the 2C19 enzyme of the complex, including many proton pump inhibitors and antiepileptic drugs, may be degraded slower if given together with CBD.
8. ADVERSE EFFECTS
According to a review of studies on of CBD this non-psychotropic cannabinoid of the cannabis plant “may be safe in humans and animals” (Bergamaschi et al. 2011). Several studies put forward that CBD is non-toxic in non-transformed cells and does not induce changes in food intake, does not induce catalepsy, does not affect physiological parameters (heart rate, blood pressure, and body temperature), does not affect gastrointestinal transit and does not alter psychomotor or psychological functions.
In cell experiments, CBD influenced the function of certain proteins (P-glycoprotein and Breast Cancer Resistance Protein), which play a role in the normal function of the placenta (Feinshtein et al. 2013). Researchers concluded that the use of CBD during pregnancy “may reduce placental protective functions and change its morphological and physiological characteristics.”